Activating and sedating ssris, recommended Posts
Weight gain Weight gain is another troubling side effect. Paroxetine appears to cause the highest rate of sexual dysfunction. Half-life The half-life of a drug is the time required to achieve steady-state plasma concentrations i.
Fluoxetine has a half-life of days and its active metabolite, norfluoxetine, has a half-life of days. Paroxetine may cause heart defects or serious, life-threatening lung problems in newborn babies whose mothers take the medication during pregnancy.
These effects may be particularly difficult to tolerate for elderly or concomitantly medically ill patients. All antidepressants do not have the same type or severity of withdrawal symptoms.
Antidepressants with relatively short half-lives are desirable for people with multiple comorbidities and complex, multiple-drug regimens because they allow for once-daily dosing. Fluoxetine is unique because of its long half-life and the long half-life of its active metabolite norfluoxetine. Dry mouth Citalopram and paroxetine are more likely to cause dry mouth than escitalopram and fluoxetine. This effect lesses as one reaches higher doses i.
Sertraline exhibits a sex- and age-dependent half-life. Paroxetine and sertraline have been associated with slightly more cases of nausea. Half-life can be used to estimate how long it will take to clear a drug from the body after treatment is discontinued.
Escitalopram and citalopram have been associated with low rates of insomnia, anxiety, and other activating side effects. Prozac at the top of activating, rechenmaschine online dating Paxil at the lowest.
Escitalopram and paroxetine are less likely to cause insomnia than fluoxetine and sertraline. Advertisement Protein binding Fluoxetine, paroxetine and sertraline are highly protein bound. Citalopram, escitalopram and sertraline show linear and dose-proportional pharmacokinetics changes in drug concentration proportional to the change in dose. It's off-label for the forum, but a quick summary might be worth mentioning. Analysis of the clinical trials suggests that fluvoxamine and fluoxetine are less likely to produce sexual side effects than paroxetine and sertraline.
Higher doses may produce much greater increases in plasma drug concentrations than would otherwise be expected. This is not from forum as far as I know or at least easily collated in one post, but I didn't search either.
Sertraline is generally associated with a small degree of weight loss in the acute phase of treatment. Headache Sertraline and fluoxetine are associated with higher level of headache. The incidence of discontinuation syndrome is highest with paroxetine followed by fluvoxamine and sertraline.
Parnate Tranylcypromine is extremely activating for some people, not at all a sedating medication. Titration of fluoxetine and paroxetine doses may therefore be more difficult than with citalopram, escitalopram and sertraline. In contrast, fluvoxamine, fluoxetine and paroxetine have non-linear pharmacokinetics. Plasma concentrations of these drugs are proportional to the daily dose administered and, therefore, predictable.
These range all over the scale from extremely activating, to neutral, to sedating. Keep in mind depression keeps most people sedated in physical and mental activity, so an activating medication may feel more neutral than activating in practice. The activating properties will increase as the dose increases.